Fig. 2: Effect of blocking CTLA-4 and Tim-3 signaling pathways on cytokines production by human dCD4+T cells. | Cell Death & Disease

Fig. 2: Effect of blocking CTLA-4 and Tim-3 signaling pathways on cytokines production by human dCD4+T cells.

From: Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4+T cells

Fig. 2

a Expression of Th1-type cytokines and transcription factors of dCD4+T cells cultured for 48 h in the presence or absence of anti-CTLA-4 antibody (10 μg/ml), anti-Tim-3 antibody (10 μg/ml), or both. b Quantification of flow cytometric analysis of IL-4 and GATA-3 expression by dCD4+T cells following treatment with the indicated blocking antibodies. c Expression of Treg-type cytokines by dCD4+T cells following treatment with the indicated blocking antibodies. Data represented the mean ± SEM. n = 12. *P < 0.05, **P < 0.01, ***P < 0.001, compared with the control group

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