Fig. 5: Cytokine production in dCD4+T cells during normal pregnancy. | Cell Death & Disease

Fig. 5: Cytokine production in dCD4+T cells during normal pregnancy.

From: Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4+T cells

Fig. 5

a Production of the pro-inflammatory cytokines TNF-α, IFN-γ and IL-17A in dCTLA-4+Tim-3+CD4+T cells and dCTLA-4−Tim-3−CD4+T cells from the first trimester of human normal pregnancies. n = 9. b Quantitation of flow cytometric analysis of IL-4, TGF-β1, and IL-10 of dCTLA-4+Tim-3+CD4+T cells and dCTLA-4−Tim-3−CD4+T cells. n = 9. c Expression of T-bet, GATA-3, Foxp3, and ROR-γt of dCTLA-4+Tim-3+CD4+T cells and dCTLA-4-Tim-3-CD4+T cells. n = 9, Data represented the mean ± SEM. The flow cytometry plots were representative of three independent experiments. *P < 0.05,**P < 0.01, ***P < 0.001, compared with dCTLA-4-Tim-3−CD4+T cells

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