Fig. 1: Metabolic activation and degradation of N-nitrosodimethylamine (NDMA) in liver.
From: Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis
The metabolic degradation of NDMA produces formaldehyde and methanol, and the alkylating intermediate reacts with nucleic acids and proteins to form methylated macromolecules
