Fig. 7: Working model of miRNAs functions in chemoresistance.
From: MiR-30a regulates cancer cell response to chemotherapy through SNAI1/IRS1/AKT pathway
MiR-30a regulates cancer cell response to chemotherapy through SNAI1/IRS1/ERK/AKT pathway. On the other hand, miR-30a is a downstream target gene of AKT-FOXO30a that forms a feedback loop. In addition, it is highly possible that other miRNAs identified by miRNA screen may also be involved in gemcitabine response and are worth exploring further
