Fig. 6: Stable knockdown of LXRα inhibits the ccRCC metastasis in mouse intrasplenical injection model.
From: LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma
a The numbers of macroscopic tumor metastases in liver in NC group were more than that in sh-LXRα group. Mouse weight was measured and the fold change of body weight were calculated in NC and sh-LXRα group. b Fluorescence images and mean fluorescence intensity values of liver were analyzed in a live imaging system. c The metastatic tumor in liver were shown as the arrow points. d H&E staining of liver were performed. Original magnifications were ×100, and ×200. e IHC assays of vimentin in liver of tumor xenograft mouse. The metastatic tumor in liver were revealed by dark brown. Original magnifications were ×100, and ×200. f Schematic representation of elevated expression of LXRα could promote the migration and invasion of ccRCC cells via regulating the NLRP3 inflammasome (Data are shown as mean ± SD. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05, and ns means no significant difference compared with the corresponding control)
