Fig. 3: Expression of MKK3 induces JNK-dependent cell invasion in wing discs. | Cell Death & Disease

Fig. 3: Expression of MKK3 induces JNK-dependent cell invasion in wing discs.

From: MKK3 modulates JNK-dependent cell migration and invasion

Fig. 3

Fluorescent (a–e, g–k, m–q) and light (f, l, r) micrographs of third instar wing discs are shown. Compared with the control (a–f), ectopic expression of MKK3 induced cell migration (g) accompanied by activation of MMP1 (h), integrin (i), TRE-RFP (j), p-JNK (k) and puc-LacZ (l), which were significantly suppressed by co-expression of Puc (m–r). Scale bars, 20 μm. Statistics of migrated cell numbers was shown in (s), and One-way ANOVA test was used to calculate statistical significance, n ≥ 14, mean + s.d., ***P < 0.001

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