Table 1 Radiation biologic parameters of ESCC cells in different groups

From: High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy

Cell lines

Group

D0 (Gy)

Dq (Gy)

N

SF2 (%)

TE-1

Control

3.34 ± 0.24

1.88 ± 0.17

1.76 ± 0.41

72.01 ± 2.50

siHMGB1

2.47 ± 0.31a,*

1.83 ± 0.11a,*

2.10 ± 0.38a, *

69.08 ± 3.70 a,*

siHMGB1 + EBSS

3.55 ± 0.26b,*

2.58 ± 0.21b,*

2.07 ± 0.35b,*

80.11 ± 1.70b,*

EBSS

3.64 ± 0.27

2.81 ± 0.18

2.16 ± 0.37

83.10 ± 1.24

Eca-109

Control

3.18 ± 0.19

1.47 ± 0.31

1.59 ± 0.04

70.32 ± 3.30

siHMGB1

2.48 ± 0.32a,*

1.44 ± 0.19a,*

1.79 ± 0.22a, *

65.71 ± 4.50a,*

siHMGB1 + EBSS

3.88 ± 0.41b,*

2.00 ± 0.23b, *

1.66 ± 0.33b, *

75.11 ± 2.90b,*

EBSS

3.98 ± 0.26

2.38 ± 0.21

1.82 ± 0.39

78.14 ± 1.40

  1. Note: Radiobiological parameters (D0, Dq, N and SF2) were calculated from the single-hit multitarget model (SF = 1−(1−e^ [−kD]) ^N) using GraphPad Prism 7.0
  2. D0: final slope; Dq: quasi-threshold dose; N: extrapolation number; SF2: survival fraction of 2 Gy
  3. *P < 0.05, t test
  4. asiHMGB1 vs. control
  5. bsiHMGB1 + EBSS vs. siHMGB1