Fig. 2: A661 and A665 are predicted to bind a pocket domain near the minor groove within the Fli-1 DNA-binding sites.

a Binding of mithramycin (MTM) near the minor pocket of EWS-FLI-1 binding site. Relative binding of MTM and A661 (b–d), MTM and A665 (f–h) to FLI-1 binding site. e Relative binding of MTM and FLI-1 to DNA within the Fli-1 binding site