Fig. 4: Human recombinant chemerin (rh-chemerin) administration attenuated oxidative stress at 24 h post hypoxic–ischemic encephalopathy (HIE). | Cell Death & Disease

Fig. 4: Human recombinant chemerin (rh-chemerin) administration attenuated oxidative stress at 24 h post hypoxic–ischemic encephalopathy (HIE).

From: RETRACTED ARTICLE: Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic–ischemic encephalopathy

Fig. 4

a Representative images of dihydroethidium (DHE; red, upper line) and 4-hydroxynonenal (4-HNE; red, lower line; NeuN, green)-positive staining in the ipsilateral cortex at 24 h after HIE. Data showed that there were greater DHE signals (b) and more positively 4-HNE-stained neurons (c) observed in vehicle group compared with sham, whereas rh-chemerin treatment markedly decreased these positively stained cells. However, chemerin receptor 23 (chemR23) small interfering RNA (siRNA) reversed rh-chemerin effects by showing increase in the number of positive stained cells. Scale bar = 100 µm; *p < 0.05 compared with sham, #p < 0.05 compared with HIE+vehicle, &p < 0.05 compared with HIE+rh-chemerin+Scramble siRNA, n = 6/group. Data are mean ± SD. Analysis of variance (ANOVA), Tukey

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