Fig. 7: A working model summarizing the mechanism of mRNA m6A modification and its modulators in regulation of piPSCs pluripotency. | Cell Death & Disease

Fig. 7: A working model summarizing the mechanism of mRNA m6A modification and its modulators in regulation of piPSCs pluripotency.

From: m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner

Fig. 7

m6A methyltransferase METTL3 increases the m6A levels of JAK2 and SOCS3 mRNA, leading to enhancing YTHDF1-mediated translation of JAK2 and attenuating YTHDF2-dependent mRNA stability of SOCS3, resulting in increased protein expression of JAK2 and decreased protein expression of SOCS3, thereby activating STAT3 phosphorylation and enhancing expression of core pluripotency genes KLF4 and SOX2 to facilitates piPSCs pluripotency

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