Fig. 2: Investigation of downstream genes regulated by MTA2 in PDAC cells.
From: MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity
a ChIP-seq analysis was performed in MIA Paca-2 cells using a specific antibody against MTA2, and the peaks’ distribution of MTA2 was determined. b The relative peaks’ chromosome distribution is shown. c KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway database was used to identify the pathways that the MTA2 target genes were involved in. d Discriminative Regular Expression Motif Elicitation was used to analyze the binding motif for MTA2. e qChIP analysis was performed in MIA Paca-2 cells using anti-MTA2 antibody to detect the binding of MTA2 on the selected target genes. Isotypic IgG served as a control. Data were expressed as fold change over the control. Error bars represent mean ± S.D. for three independent experiments. *P < 0.05; **P < 0.01. f The relative expression of PTEN was measured in different PDAC cohorts in GSE28735, PACA-AU ICGC, and TCGA databases
