Fig. 8: Schematic representation of the miR-185/Bgn/BMP-Smad1/5/8 signaling. | Cell Death & Disease

Fig. 8: Schematic representation of the miR-185/Bgn/BMP-Smad1/5/8 signaling.

From: Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway

Fig. 8

In this mechanism, during the osteogenic differentiation, the depletion of miR-185 upregulated Bgn expression, so as to activate the BMP/Smad1/5/8 signaling. The calvarial osteoblasts and mesenchymal stem cells (MSCs) of knockout (KO) mice exhibited increased osteogenic differentiation ability, and KO mice was protected during osteoporosis. miR-185, microRNA-185; Bgn, biglycan

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