Fig. 5: miR-29a-mediated SUV420H2 decrease trimethylation of H4K20 and promotes EMT progress in MCF-7 cells. | Cell Death & Disease

Fig. 5: miR-29a-mediated SUV420H2 decrease trimethylation of H4K20 and promotes EMT progress in MCF-7 cells.

From: miR-29a contributes to breast cancer cells epithelial–mesenchymal transition, migration, and invasion via down-regulating histone H4K20 trimethylation through directly targeting SUV420H2

Fig. 5: miR-29a-mediated SUV420H2 decrease trimethylation of H4K20 and promotes EMT progress in MCF-7 cells.

a SUV420H2 and H4K20me3 protein levels in MCF-7 cells transfected with either the scrambled negative control RNA, miR-29a mimic, or miR-29a inhibitor. b SUV420H2 and H4K20me3 protein levels in MCF-7 cells transfected with either the control vector, SUV420H2 vector, control siRNA, or SUV420H2 siRNA. c SUV420H2 and H4K20me3 protein levels in MCF-7 cells transfected with either the control mimic plus control vector, miR-29a mimic plus control vector, or miR-29a mimic plus SUV420H2 vector. d Immunofluorescent staining of E-cadherin and Vimentin in MCF-7 cells transfected with either the control mimic plus control vector, miR-29a mimic plus control vector, control mimic plus SUV420H2 vector, or miR-29a mimic plus SUV420H2 vector. **P < 0.01

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