Fig. 7: Effects of SUV420H2-targeted miR-29a on the lung colonization of MCF-7 cells xenografts in mice. | Cell Death & Disease

Fig. 7: Effects of SUV420H2-targeted miR-29a on the lung colonization of MCF-7 cells xenografts in mice.

From: miR-29a contributes to breast cancer cells epithelial–mesenchymal transition, migration, and invasion via down-regulating histone H4K20 trimethylation through directly targeting SUV420H2

Fig. 7: Effects of SUV420H2-targeted miR-29a on the lung colonization of MCF-7 cells xenografts in mice.

a, b miR-29a levels (a), SUV420H2 protein and H4K20me3 levels (b) in MCF-7 cells transfected with either the control lentivirus, miR-29a lentivirus, SUV420H2 lentivirus or miR-29a lentivirus plus SUV420H2 lentivirus. c Experimental design. Immunocompromised mice were injected through tail vein with MCF-7 cells transfected with either the control lentivirus, miR-29a lentivirus, SUV420H2 lentivirus or miR-29a lentivirus plus SUV420H2 lentivirus. d Representative BLI images of four groups. The BLI was performed on days 7, 28, and 56 after injection. The intensity of BLI is represented by the color. e The numbers of tumor nodules in the lungs. Results were derived from five mice in each group. f, g Mouse lungs were subjected to H&E staining (f) and immunohistochemical staining for SUV420H2 and H4K20me3 (g), respectively. **P < 0.01

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