Fig. 3: Evaluation of oxidized ATM-mediated EMR in TNBC cells in the presence or absence of hypoxia. | Cell Death & Disease

Fig. 3: Evaluation of oxidized ATM-mediated EMR in TNBC cells in the presence or absence of hypoxia.

From: RETRACTED ARTICLE: Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis

Fig. 3

BT549 and Hs578T parent cells or ATM-knocked down cells were cultured with indicated treatment. a Glucose consumption, b pyruvate,c lactate, and d acetyl-CoA productions were measured according to instruction of reagent kit, respectively. e Maximal OCR stimulated with FCCP are shown. f Mitochondrial mass was assessed with Mitotracker staining. Relative mitochondrial activities in cells treated with KU60019 or ATM-silenced cells are showed as relative fold changes to their controls. (NS, no significance; *P < 0.05; **P < 0.01)

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