Fig. 2: Autophagy deficiency enhances inflammatory cell infiltration during UUO. | Cell Death & Disease

Fig. 2: Autophagy deficiency enhances inflammatory cell infiltration during UUO.

From: ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury

Fig. 2: Autophagy deficiency enhances inflammatory cell infiltration during UUO.The alternative text for this image may have been generated using AI.

ATG5+/+ and ATG5−/− mice were subjected to either sham operation or UUO, and kidney tissues were harvested after 7 days. a Representative H&E staining showed the morphologic injury and inflammatory cells infiltration. Scar bar: 20 μm. b Representative images of F4/80 staining (green) and DAPI (blue). Scale bar: 20 um. c Quantification of F4/80 positive cells. Data are expressed as mean ± SEM (n = 6); *P < 0.05 vs. sham; #P < 0.01 vs. obstructed kidney of ATG5+/+ mice. d Representative images of CD3 staining (red) and DAPI (blue). Scar bar: 20 μm. e Quantification of CD3 positive cells. Data are expressed as mean ± SEM (n = 6); *P < 0.05 vs. sham; #P < 0.01 vs. obstructed kidney of ATG5+/+ mice

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