Fig. 4: Metabolic reprogramming of senescent CD8+ T cells from patients with prediabetes.
From: T-cell senescence contributes to abnormal glucose homeostasis in humans and mice
a, b The production of ROS was monitored by DCF fluorescence and quantified as the MFI in CD4+CD28− T cells from normoglycemic subjects (n = 6) and patients with prediabetes (n = 6). c, d The production of ROS was monitored by DCF fluorescence and quantified as the MFI in CD8+CD28− T cells from normoglycemic subjects (n = 6) and patients with prediabetes (n = 6). e, f Oxygen consumption rate and extracellular acidification rate (ECAR), measured in CD8+CD28− T cells from normoglycemic subjects (n = 6) and patients with prediabetes (n = 6). g Extracellular acidification rate (ECAR), measured in activated CD8+CD28− T cells from normoglycemic subjects (n = 6) and patients with prediabetes (n = 6). Data are expressed as mean ± SEM. *P < 0.05 compared with the corresponding controls
