Fig. 7: PD-L2 knockdown inhibits osteosarcoma cells metastasis in vivo. | Cell Death & Disease

Fig. 7: PD-L2 knockdown inhibits osteosarcoma cells metastasis in vivo.

From: Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways

Fig. 7

a Tumor growth curves and tumor weights were evaluated between shPD-L2 and shNC groups. No significant difference was observed between the two groups. b Representative images of primary tumors. c The metastatic frequency of shNC and shPD-L2 groups. d H&E staining of the lungs of shNC and shPD-L2 groups (magnification × 16 and × 100). Arrows indicate metastases. e, f Primary tumors were collected and evaluated by IHC (magnification × 400) and western blotting. g A diagrammatic sketch of PD-L2 in osteosarcoma metastasis. Data are presented as the mean ± SD (n = 4)

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