Fig. 1: Akirin2 is upregulated in human cholangiocarcinoma (CCA) and predicts a poor prognosis. | Cell Death & Disease

Fig. 1: Akirin2 is upregulated in human cholangiocarcinoma (CCA) and predicts a poor prognosis.

From: Akirin2 is modulated by miR-490-3p and facilitates angiogenesis in cholangiocarcinoma through the IL-6/STAT3/VEGFA signaling pathway

Fig. 1: Akirin2 is upregulated in human cholangiocarcinoma (CCA) and predicts a poor prognosis.

a Akirin2 mRNA expression was markedly elevated in CCA tissues relative to their normal counterparts determined by RT-qPCR. b Western blot analysis was employed to confirm the expression of Akirin2 in human CCA compared with the adjacent normal tissues. T tumors, N adjacent normal tissues. c Representative images of Akirin2 immunohistochemistry (IHC) staining in normal bile duct tissues and CCA tissues. d Kaplan–Meier analysis indicating the correlation between the prognosis of CCA patients and the high/low expression of Akirin2. e Relative Akirin2 mRNA levels in human intrahepatic biliary epithelial cell (HiBEC) and CCA cell lines by RT-qPCR. f Western blot analysis of Akirin2 in HiBEC and five CCA cell lines were performed on separated cell fractions: the nuclear fraction (left blot) and the cytoplasmic fraction (right blot). **P < 0.01; ***P < 0.001. Data are shown as mean ± SD of at least three independent experiments

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