Fig. 4: LINC01048 was transcriptionally activated by USF1. | Cell Death & Disease

Fig. 4: LINC01048 was transcriptionally activated by USF1.

From: USF1-induced upregulation of LINC01048 promotes cell proliferation and apoptosis in cutaneous squamous cell carcinoma by binding to TAF15 to transcriptionally activate YAP1

Fig. 4

a, b The binding motif of USF1 and the top three binding sequences were obtained from JASPAR. c ChIP assay revealed that E1 fragment (from −1441 to −1431 bp), but not E2 (from −835 to −825 bp), or E3 (from −561 to −551 bp), was responsible for the affinity of USF1 to LINC00148 promoter. d Luciferase reporter assay revealed that region from from −1500 to +1 of LINC01048 promoter driven the luciferase activity. e, f Relative high expression level of USF1 in CSCC tissues and cell lines. g The expression correlation between USF1 and LINC01048 in CSCC tissues. **p < 0.01 vs. control group

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