Fig. 8: Subcutaneous xenograft model and drug therapy in nude mice. | Cell Death & Disease

Fig. 8: Subcutaneous xenograft model and drug therapy in nude mice.

From: Bromocriptine and cabergoline induce cell death in prolactinoma cells via the ERK/EGR1 and AKT/mTOR pathway respectively

Fig. 8

a Schematic representation of the experimental procedure employed to study tumours in nude mice. Tumour formation was observed, and tumourigenic nude mice were randomly divided into a control group and a BRC treatment group (n = 5). b Representative images of xenograft tumours in nude mice. c The tumour volume on the nude mouse. d Representative images of the tumour samples from each group. e The tumour weight of each group. f The TUNEL staining and immunohistochemical analyses of EGR1 and p-ERK in tumour samples of each group. g The proposed mechanism of BRC- and CAB-induced cell death in prolactinoma cells

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