Fig. 5: Effect of EP on phosphorylation of Src/ERK and levels of p27. | Cell Death & Disease

Fig. 5: Effect of EP on phosphorylation of Src/ERK and levels of p27.

From: Blockade of HMGB1 signaling pathway by ethyl pyruvate inhibits tumor growth in diffuse large B-cell lymphoma

Fig. 5

Tumor cells were isolated from solid tumor by separating cells from connective tissue. Fifteen lymphoma tissues from NaCl, 40 mg/kg and 80 mg/kg EP injected, five in each group were lysed for western blotting. a Western blotting analysis of the effect of EP on p-Src, p-ERK, CDK2, and p27. Condition of each antibody is listed in Suppl Table 1. b, c Statistical analysis of EP-induced inhibition of p-SRC and p-ERK. d, e Statistical analysis of EP-induced inhibition of CDK2 and accumulation of p27. Statistical analyses were as same as mentioned in Fig. 3

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