Fig. 3: Exploration of cell death induced by JQ1 in vitro. | Cell Death & Disease

Fig. 3: Exploration of cell death induced by JQ1 in vitro.

From: Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

Fig. 3

a Expression of BRD4 in different types of BRCA cell lines from the Cancer Cell Line Encyclopedia database. b The apoptosis inhibitor Z-VAD-FMK (10 μM) did not fully reverse the anticancer effect of JQ1 (10 μM) in the MDA-MB-231 and Hs578T BRCA cell lines or the A549 and H1299 LUAD cell lines. c A necrosis inhibitor nec-1 (20 μM) did not influence the viability of cells treated with JQ1 (10 μM) plus Z-VAD-FMK (10 μM) in the MDA-MB-231 and Hs578T BRCA cell lines or the A549 and H1299 LUAD cell lines. An equal volume of dimethyl sulfoxide was used as the control; cell viability was assessed after the application of the drugs for 24 h. *P < 0.05, **P < 0.01, ***P < 0.001. The data represent the results of at least three independent experiments

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