Fig. 5: The anticancer effect of JQ1 is suppressed by fer-1 in vivo. | Cell Death & Disease

Fig. 5: The anticancer effect of JQ1 is suppressed by fer-1 in vivo.

From: Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

Fig. 5

a Tumors in the JQ1 (50 mg/kg) group were smaller than those in the dimethyl sulfoxide (DMSO) group and the JQ1 (50 mg/kg) plus fer-1 (1 mg/kg) group. b The immunohistochemical results showed that BRD4 expression in tumors in the JQ1 group and the JQ1 plus fer-1 group was lower than that in tumors in the DMSO group. c Tumor sample volumes are shown using a time-course line graph. d The weight of tumors in the JQ1 group was lower than that of tumors in the DMSO group and the JQ1 plus fer-1 group. e The level of iron was increased with JQ1 treatment but was not influenced by fer-1 treatment. f The level of reactive oxygen species was increased with JQ1 treatment and was decreased with fer-1 treatment. The data are presented as the means ± SDs. An equal volume of DMSO was used as the control. Scale bar = 50 μm. *P < 0.05, **P < 0.01, ***P < 0.001

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