Fig. 5: NMN increases the expansion of BM MSCs in irradiated adult mice. | Cell Death & Disease

Fig. 5: NMN increases the expansion of BM MSCs in irradiated adult mice.

From: Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow

Fig. 5

a Scheme of NMN administration followed by CFU-F and flow cytometry. b–c Representative images (b) and number of CFU-F colonies (c) formed by MSCs. d–f The PDGFRα+ MSCs (d) and LepR+ MSCs (f) from enzymatically dissociated femur bone marrow cells. e The frequency of LepR+ MSCs, PDGFRα+ MSCs, and PDGFRα+ LepR+ MSCs from enzymatically dissociated femur bone marrow cells. g The cellularity of the enzymatically dissociated femur bone marrow cells (n = 6 mice per group, from three independent experiments). *p < 0.05, **p < 0.01 error bars, s.d.

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