Fig. 1: Oridonin inhibited cardiomyocyte hypertrophy.
From: Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy
a A-actinin staining of the cardiomyocytes incubated with different doses of oridonin (5, 20 and 50 μM) in response to Ang II for 12–24 h. Representative images show the inhibitory effect of oridonin on the enlargement of myocytes (scale bar: 20 μm). b Statistical results of cell area by measuring random cells (n = 50 cells). c Real-time PCR analyses of the hypertrophy markers atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and β-myosin heavy chain (β-MHC) (n = 6). Data are represented as the means ± SD. *P < 0.05 versus vehicle cells; #P < 0.05 versus Ang II-treated cells, §P < 0.05 between different doses of oridonin
