Fig. 2: Oridonin ameliorated cardiac hypertrophy and dysfunction induced by pressure overload.
From: Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy
a, b Histological analysis of whole hearts and heart sections stained with HE 4 weeks post AB surgery (scale bar: 1000 μm and 20 μm, n = 6). c Statistical results for the cross-sectional areas of myocytes (CSA, n = 100 cells). d Statistical results of heart weight/body weight (HW/BW) and heart weight/tibia length (HW/TL) (n = 12–15). e Real-time PCR analyses of the transcriptional levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and β-myosin heavy chain (β-MHC) (n = 6). f Representative M-mode echocardiograms of indicated groups 4 weeks after surgery (n = 6). g, h Echocardiographic parameters of each group of mice (n = 6). i Haemodynamic parameters in oridonin-treated mice (n = 6). Data are represented as the means ± SD. *P < 0.05 versus vehicle-sham. #P < 0.05 versus vehicle-AB
