Fig. 4: Perifosine regulates RAD51 ubiquitination by inhibiting UCHL3. | Cell Death & Disease

Fig. 4: Perifosine regulates RAD51 ubiquitination by inhibiting UCHL3.

From: A novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Fig. 4

a Control and UCHL3 knockout MDA-MB-231 cells were treated with perifosine and lysates were used for immunoprecipitation and western blot as indicated. b Examination of Rad51 ubiquitination in cells treated with perifosine. c In vitro deubiquitination analysis of UCHL3 in the presence or absence of perifosine

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