Fig. 3: Deletion of Brca2 in oocytes impairs ovarian development.
From: BRCA2 deficiency is a potential driver for human primary ovarian insufficiency
a Representative images of ovarian size from control and Brca2-deficient mice. Scale bar, 200 μm. b Average weights of ovaries obtained from control and Brca2-deficient females. Data are shown as mean ± SEM. c–f Histology of ovarian sections from young adult control and Brca2-deficient females. Ovaries from 2-month-old mice were embedded in paraffin, and sections of 8 μm thickness were prepared and stained with H&E. Black arrows in (d) show the growing follicles at different developmental stages; yellow arrows in (f) indicate the developmentally arrested follicles with degenerating oocytes. CL, corpus luteum. Scale bars in (c) and (e), 250 μm; scale bars in (d) and (f), 50 μm. g Quantification analysis of primordial follicles between control and Brca2-deficient ovaries. h Quantification analysis of activated follicles between control and Brca2-deficient ovaries. Brca2-deficient ovary contained a significantly increased number of activated follicles with developmental arrest and degraded oocytes compared with the control ovary
