Fig. 4: CTRP3 regulates activation of the p38 MAPK/CREB pathway in TAC mouse. | Cell Death & Disease

Fig. 4: CTRP3 regulates activation of the p38 MAPK/CREB pathway in TAC mouse.

From: C1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress

Fig. 4

a, b Representative western blot (top) and quantification (bottom) of the p38-CREB signaling pathway activity in the hearts of mice with different genotypes (WT, Ctrp3-KO, and LV-CTRP3) 4 weeks after sham treatment or TAC surgery (n = 5–6 mice per group). c, d Representative immunofluorescence images of murine heart sections stained with p-p38 (red) and DAPI (blue) (left), and the percentage of p-p38–positive nuclei (right) in the hearts of mice with different genotypes (WT, Ctrp3-KO, and LV-CTRP3) 4 weeks after sham treatment or TAC surgery (n = 5–6 mice per group). The data were analyzed by one-way ANOVA. *p < 0.05, **p < 0.01 vs. SHAM, #p < 0.05 vs. TAC. In the bar graphs, the data are presented as the mean ± SEM

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