Fig. 4: Effects of FMDV proteins synergized with PCBP2 on VISA-triggered signaling. | Cell Death & Disease

Fig. 4: Effects of FMDV proteins synergized with PCBP2 on VISA-triggered signaling.

From: Poly (rC) binding protein 2 interacts with VP0 and increases the replication of the foot-and-mouth disease virus

Fig. 4: Effects of FMDV proteins synergized with PCBP2 on VISA-triggered signaling.

a–g Effects of L a, 2C b, 2B c, 3D d, 3A e, VP0 f, and VP2 g proteins of FMDV synergized with PCBP2 on VISA-triggered activation of IFN-β promoter. HEK293T cells (1 × 105) were transfected with IFN-β reporter (0.1 μg) and the indicated expression (0.1 μg) plasmids for 24 h before luciferase assays were performed. h Effects of 2B, 2C, 3D, and VP0 proteins of FMDV synergized with PCBP2 on VISA-triggered activation of IFN-β promoter. The experiments were performed similar to those described in a. The data represent the mean ± SD of the three independent experiments (*p < 0.05; **p < 0.01). EV empty vector, Luc luciferase, Con control

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