Fig. 6: The apoptosis changes of U87 cells induced by combined treatment of KHDRBS3, cDENND4C, and miR-577 with doxorubicin.
From: KHDRBS3 regulates the permeability of blood–tumor barrier via cDENND4C/miR-577 axis
a The schematic diagram of the BTB model in vitro used to evaluate the Dox penetration. Representative flow cytometric detection b and analysis of the U87 cell apoptosis rates in different groups c. Data represented as mean ± SD (n = 3). *P < 0.05 vs. control group, #P < 0.05 vs. DOX group, §P < 0.05 vs. DOX + KHDRBS3 knockdown GECs group, &P < 0.05 vs. DOX + cDENND4C-knockdown GECs group, ※P < 0.05 vs. DOX + miR-577 overexpressed GECs group, ▲▲P < 0.01 vs. DOX + KHDRBS3 and cDENND4C double knockdown GECs group, ▲P < 0.01 vs. DOX + cDENND4C knockdown combined with miR-577 overexpressed GECs group. d The schematic diagram of the mechanism by which KHDRBS3 regulates the BTB permeability via cDENND4C/miR-577 axis
