Table 1 Main pharmacokinetic parameters of Fenretinide in CD1 female mice after administration of Nanofenretinide by oral or intravenous route in comparison with the NCI capsules and pure Fenretinide administered at the same dose (5 mg/Kg fenretinide)

From: A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors

Pk parameters

NanoFEN i.v.

PureFEN i.v.

NanoFEN p.o.

NCI p.o.

Units

AUC 0-last

13563.5

6420.32

9378.9

3201

h*ng/ml

AUC inf

13656.8

6574.35

9382.5

3209.7

h*ng/ml

Ke

0.094

0.088

0.106

0.089

1/h

HL

7.41

7.87

6.54

7.79

h

Tmax

–

–

4

2

h

Vd

3.9

6.52

–

–

L/kg

Cmax

6932.6

4134.77

730.06

298.13

ng/ml

Cl

0.366

0.574

–

–

L/hr/kg

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