Fig. 4: Effect of miR-493-5p rescue on hepatic cancer cell malignancy. | Cell Death & Disease

Fig. 4: Effect of miR-493-5p rescue on hepatic cancer cell malignancy.

From: MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells

Fig. 4

a Tumor cell growth evaluated after miR-493-5p rescue. The number of cells was estimated after miR-493-5p overexpression using cell viability assays. Cells transfected with control mimics (miR-Ctrl mimic) were used as a reference. The data represent the mean ± SD. b Invasive abilities of Hep3B cells after miR-493-5p re-expression. Cells that migrated through the Matrigel-coated membrane were counted after 72 h. The histograms show the mean ± SD. c HCC tumor growth in response to miR-493-5p rescue. The data show the mean ± SEM calculated for tumors in the control (n = 9) and miR-493 group (n = 9). The pictures show representative tumor sizes at the end of the experiment: 4619.6 ± 1072.1 mm3 and 422.7 ± 86.1 mm3 for the control (Ctrl Hep3B) and miR-493 group (miR-493 Hep3B), respectively. Significant differences in cell migration and tumor growth (in vitro and in vivo) were evaluated with a t-test: *p < 0.05, **p < 0.01, and ***p < 0.001

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