Fig. 6: Inhibition of STAT5-PI3K/Akt pathway prevent the raising of SLAMF3 induced by palmitic acid on human T cells.

a Jurkat T cells were cultured in the presence of palmitic acid (PA, 0 or 0.15 mM) with or without PI3K inhibitor, LY294002 (LY, 10 or 50 μM) for 3 days. Representative flow cytometric profiles (left) and summarized data (right; mean ± SDs, n = 4/each) about SLAMF3 expression were shown. (Data shown are results from a representative of three experiments.) b Jurkat T cells were cultured in the presence of palmitic acid (PA, 0 or 0.15 mM) with or without STAT5 inhibitor, sc-355979 (Si, 20 or 50 μg/ml) for 3 days. Representative flow cytometric profiles (left) and summarized data (right; mean ± SDs, n = 4/each) about SLAMF3 expression were shown. (Data shown are results from a representative of three experiments.) ***p < 0.001; ns no significant difference