Fig. 4: ChIP-Seq analysis shows major NIPBL localization at promoter regions. | Cell Death & Disease

Fig. 4: ChIP-Seq analysis shows major NIPBL localization at promoter regions.

From: The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes

Fig. 4

a Sectors diagram indicating the percentage of NIPBL peaks, as determined through ChIP-Seq analysis, at transcription start sites (TSS) or out of TSS (no TSS). b Venn diagrams showing the number of genes with NIPBL peaks overlapping either with genes regulated by NIPBL or with genes commonly downregulated upon NIPBL and BRD4 depletion, i.e., genes dependent on both proteins. Numbers on the diagrams indicate the total number of genes in each condition. Percentage of overlapping genes, referred to the total number of regulated genes in each analysis is also shown. c NIPBL localization on genes selected for further studies is shown. y-axis denotes ChIP signal amplitude, while x-axis indicates genome positions

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