Fig. 6: IL-8-targeting shRNAs suppress the growth and metastasis of primary tumors and inhibit CTC self-seeding and angiogenic activity in vivo. | Cell Death & Disease

Fig. 6: IL-8-targeting shRNAs suppress the growth and metastasis of primary tumors and inhibit CTC self-seeding and angiogenic activity in vivo.

From: Self-seeding circulating tumor cells promote the proliferation and metastasis of human osteosarcoma by upregulating interleukin-8

Fig. 6

a Representative images of primary C-F5M2 and C-F5M2 + IL-8shRNA tumors in nude mice. b Tumor volumes were smaller in the C-F5M2 + IL-8shRNA group than in the control C-F5M2 group (P < 0.05). c Representative images of lung metastases from F5M2 and C-F5M2 + IL-8shRNA tumors in nude mice. d In the C-F5M2 group, 27 mice were alive, and self-seeding was observed in 21 mice. In the C-F5M2 + IL-8shRNA group, 30 mice were alive, and self-seeding was observed in 11 mice. e Pulmonary metastases were observed in 25 mice in the C-F5M2 group and in 16 mice in the C-F5M2 + IL-8shRNA group. f IHC analysis for CD31 showed that C-F5M2 tumors had more vessels than did the C-F5M2 + IL-8shRNA tumors

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