Fig. 8: Fluoxetine protected astrocytes in vivo and ameliorated depressive-like behaviors via promoting autophagy. | Cell Death & Disease

Fig. 8: Fluoxetine protected astrocytes in vivo and ameliorated depressive-like behaviors via promoting autophagy.

From: The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression

Fig. 8: Fluoxetine protected astrocytes in vivo and ameliorated depressive-like behaviors via promoting autophagy.

a, b Immunofluorescence images and cell counts of hippocampal GFAP+ astrocytes in fluoxetine and 3-MA treated CMS mice. Scale bar: 500 μm. c, d Immunofluorescence images of astrocytic morphology and quantitative analysis of total branch numbers in each group. Scale bar: 20 μm, n = 6. e, f Immobility time of fluoxetine and 3-MA treated CMS mice in FST and TST, respectively. n = 12, data are expressed as mean ± SD. *p < 0.05, **p < 0.01 vs. Con group, #p < 0.05, ##p < 0.01, ###p < 0.001 vs. CMS group, $p < 0.05, $$p < 0.01 vs. CMS+FLX group

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