Fig. 2: ERα decreases BCa cell invasion by downregulating circ_0023642.
From: ERα-mediated alterations in circ_0023642 and miR-490-5p signaling suppress bladder cancer invasion
a Real-time PCR analysis of circRNAs related to BCa progression in UMUC3 cells overexpressing ERα or the vector (Ctrl) and J82 cells expressing shERα or the shLuc control (Ctrl). b Among the circRNAs screened, circ_0023642 and circ_0072088 expression were downregulated to the greatest extent by ERα. We knocked down circ_0023642 and circ_0072088 in UMUC3 cells and overexpressed circ_0023642 in J82 cells. Matrigel invasion assays were performed using UMUC3 and J82 cells that were transduced with the vectors described above. c Matrigel invasion assays were performed using UMUC3 cells transfected with/without oeERα or circ_0023642 and J82 cells transfected with/without shERα or shcirc_0023642. Values are presented as relative invasion (fold). *P < 0.05
