Fig. 3: Increased lipid synthesis in L-TKO mice. | Cell Death & Disease

Fig. 3: Increased lipid synthesis in L-TKO mice.

From: mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma

Fig. 3

a RNA-seq showed significantly upregulated in biological process of lipid synthesis genes based on the ratio of L-TKO/control mice of indicated ages (n ≥ 4). b Related hepatic mRNA (qPCR) from 10-month-old L-TKO and control mice (n = 7, ***P <0.001). c, d Metabolome analysis showed increased steatosis in 10-month-old L-TKO mice compared with 6-month-old L-TKO mice (n = 10). e, f Increased fatty acids and decreased glucose were observed in 10-month-old L-TKO compared with controls (n = 10). g, h SREBP1(m), ACC1, and FASN proteins were assessed by western blot at 6-month-old (g) and 10-month-old (h) L-TKO mice and controls. Western blots were quantified. n ≥ 6, ***P <0.001

Back to article page