Fig. 3: Comparison of uPA activity in PC3L1-HPN and isogenic PC3L1-HPNS353A cell populations in the absence vs. presence of dox. | Cell Death & Disease

Fig. 3: Comparison of uPA activity in PC3L1-HPN and isogenic PC3L1-HPNS353A cell populations in the absence vs. presence of dox.

From: Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

Fig. 3

Left diagram: the blank-corrected median intensity values reporting cleavage of an uPA-specific chromogenic substrate were recorded during a 4 h incubation. Linear regression curves and standard errors were determined using four technical replicates, respectively (n = 4). UK122 (50 µM) was added 24 h prior to the measurement of uPA activity. The right diagram shows the corresponding slopes of the linear regression curves. The figure shows exemplary data for one out of two experiments with similar results. Cell populations were color coded as indicated in the legend.

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