Fig. 6: Overexpression of wild-type hepsin induces cytoplasmic localization of the enzyme and autophagy in CAM xenografts. | Cell Death & Disease

Fig. 6: Overexpression of wild-type hepsin induces cytoplasmic localization of the enzyme and autophagy in CAM xenografts.

From: Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

Fig. 6

PC3L1-HPN and PC3L1-HPNS353A cells were transplanted on the CAM and grown in the absence and presence of dox (100 ng/ml, topical application for 72 h). Exemplary micrographs show the expression of hepsin and LC3B in the indicated tumors at tenfold magnification (scale bar: 100 µm) and 40-fold magnification (scale bar: 20 µm). Note the cytoplasmic localization of wild-type vs. membraneous localization of proteolytically inactive hepsin. Cells containing LC3B punctae are exemplary indicated by arrows.

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