Fig. 10: PERK inhibitor alleviated the effect of PUM1 knockdown on cell migration, invasion, and EMT in MIA PaCa-2 and PANC-1 cells. | Cell Death & Disease

Fig. 10: PERK inhibitor alleviated the effect of PUM1 knockdown on cell migration, invasion, and EMT in MIA PaCa-2 and PANC-1 cells.

From: PUM1 knockdown prevents tumor progression by activating the PERK/eIF2/ATF4 signaling pathway in pancreatic adenocarcinoma cells

Fig. 10

Effect of the PERK inhibitor GSK2606414 or DMSO on cell migration (a) and invasion (b) in shRNA or NC cells detected by Transwell assays. Left: Representative graph. Right: Bar graph of the statistical result of the migratory or invasive cells. c Effect of the PERK inhibitor GSK2606414 or DMSO on the expression of MMP9, VEGF, vimentin, and E-cadherin in shRNA or NC cells. Up: Representative graph of western blotting. Bottom: Statistical result of the relative protein expression in reference to GAPDH. n = 3, *P < 0.05, shPUM1 + DMSO vs. shPUM1 + GSK2606414; n = 3, #P < 0.05, NC + DMSO vs. NC + GSK2606414, for a–c

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