Fig. 6: PUM1 knockdown activated the PERK/eIF2/ATF4 signaling pathway.

Volcano plot (a), scatter plot (b), and cluster gram (c) of the cDNA microarrays. d Effect of PUM1 knockdown on the expression of key components of the eIF2 signaling pathway. Left: Representative graphs of western blotting. Right: Statistical result of the relative protein expression in reference to GAPDH. n = 3, *P < 0.05