Fig. 8: PERK overexpression inhibited cell proliferation, migration, invasion, and EMT and promoted apoptosis in MIA PaCa-2 and PANC-1 cells. | Cell Death & Disease

Fig. 8: PERK overexpression inhibited cell proliferation, migration, invasion, and EMT and promoted apoptosis in MIA PaCa-2 and PANC-1 cells.

From: PUM1 knockdown prevents tumor progression by activating the PERK/eIF2/ATF4 signaling pathway in pancreatic adenocarcinoma cells

Fig. 8

a PERK expression levels in MIA PaCa-2 and PANC-1 cells transfected with PERK overexpression vector (ov-PERK) or empty vector (vector). b Effect of PERK overexpression on the OD value at 490 nm. c Effect of PERK overexpression on early apoptosis rate. d Effect of PERK overexpression on cell migration and invasion detected by Transwell assays. e Effect of PERK overexpression on the expression of MMP9, VEGF, vimentin, and E-cadherin. a, c–e The representative graphs are on the left, and the statistical results are on the right. n = 3, *P < 0.05

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