Fig. 9: PERK inhibitor GSK2606414 alleviated the effects of PUM1 knockdown on cell proliferation and apoptosis in MIA PaCa-2 and PANC-1 cells. | Cell Death & Disease

Fig. 9: PERK inhibitor GSK2606414 alleviated the effects of PUM1 knockdown on cell proliferation and apoptosis in MIA PaCa-2 and PANC-1 cells.

From: PUM1 knockdown prevents tumor progression by activating the PERK/eIF2/ATF4 signaling pathway in pancreatic adenocarcinoma cells

Fig. 9

a Effect of the PERK inhibitor GSK2606414 or DMSO on OD value at 490 nm in shRNA or NC cells. b Effect of PERK inhibitor GSK2606414 or DMSO on early apoptosis rate in shRNA or NC cells. Left: Representative graphs of flow cytometry analysis for apoptosis. Right: Statistical result of early apoptosis rate for each group. n = 3, *P < 0.05, shPUM1 + DMSO vs. shPUM1 + GSK2606414; n = 3, #P < 0.05, NC + DMSO vs. NC + GSK2606414

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