Fig. 2: Reduced Level of GLI1 and SMO but no significant change of GLI2 in vitro and in vivo after vismodegib treatment. | Cell Death & Disease

Fig. 2: Reduced Level of GLI1 and SMO but no significant change of GLI2 in vitro and in vivo after vismodegib treatment.

From: Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production

Fig. 2

a, b Decreased mRNA levels of SMO and GLI1 in LUAD cells after vismodegib (30 μM) treatment. c No significant changes of GLI2 transcription in LUAD cells after vismodegib treatment. d Notable inhibitory effect on GLI1 and SMO but limited changes on cleavage PARP and GLI2 induced by vismodegib treatment in A549 and NCI-H1975 xenograft tumors. Both the RT-PCR and western blot analysis have been repeated for three times

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