Fig. 4: Enhanced cytotoxic effect of vismodegib in LUAD cells after autophagy blockage. | Cell Death & Disease

Fig. 4: Enhanced cytotoxic effect of vismodegib in LUAD cells after autophagy blockage.

From: Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production

Fig. 4: Enhanced cytotoxic effect of vismodegib in LUAD cells after autophagy blockage.

a, c Autophagy blockage by siRNAs against ATG5 and ATG7. Cells were transfected with ATG5 and ATG7 siRNAs for 48 h and then lysed for western blot analysis. Sicontrol is a sequence that anti-luciferase and is used as a negative control. b, d Enhanced cytotoxic effect of vismodegib in LUAD cells after ATG5 and ATG7 knockdown. The MTT assay has been repeated for three times

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