Fig. 3: MLN4924 enhances TNF-induced cell death in a subset of myeloma cell lines. | Cell Death & Disease

Fig. 3: MLN4924 enhances TNF-induced cell death in a subset of myeloma cell lines.

From: The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death

Fig. 3

a Myeloma cell lines were challenged overnight in technical triplicates with the indicated combinations of TNF and MLN4924 (20 µM) and analyzed for cell viability. b RPMI-8226, MM.1S and KMS-12BM cells untreated or treated with TNF (100 ng/ml), MLN4924 (20 µM) or a mixture of both for 18 h were analyzed by Western blotting for processing of the indicated proteins. Data shown are representative of at least two independent experiments

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