Table 3 Primary samples derived of myeloma patients

From: The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1+ subgroup of multiple myeloma cells for TNF-induced cell death

Patient#

Sample#

Age

Gender

Ig subtype

Stage

Therapies

FISH

1

1

64

f

IgG lambda

III A

None

Tri9q

 

2

64

f

IgG lambda

III A

3× RADa

Tri9q

2

3

50

m

IgG kappa

III A

Dexab 4× RAD 2× HD-Melc Lend

Normal

3

4

73

m

IgG kappa

I A

None

Hyperdiploide CMYC-Rearrangement

4

5

58

f

IgG lambda

I A

None

Amp1q21

5

6

78

f

IgG lambda

II A

None

6

7

72

m

IgG kappa

I A

None

7

8

43

m

IgA kappa

III A

None

Hyperdiploid

8

9

68

f

IgG kappa

III A

None

Hyperdiploid

9

10

49

f

IgG kappa

III A

None

Tri9q

10

11

61

m

Kappa LC

III B

3× ID > 2× HD-Mel; VRCDe > HD-Mel; VRCD

Normal

11

12

67

m

IgG lambda

II A

None

Hyperdiploid

12

13

62

m

Kappa LC

II A

None

Tri1q

  1. aradiation
  2. bdexamethason
  3. chigh-dose melphalan
  4. dlenalodimide
  5. ebortezomib dexamethasone thalidomide cyclophosphamide